The Biobank is starting to return some genetic results to participants who have had a blood sample drawn and processed and who have consented to have their results returned. At this time, we are only returning one test result, which may provide valuable insight into how you may respond to certain medications. Below is an example of what this report looks like with detailed explanations of each area of the report.
When you take a medicine (or a drug), your body needs to find a way to use it. Some proteins in your body break down (or metabolize) medicines. Breaking down a medicine can make it more or less active, based on the medicine.
Cytochrome P450 is a family of proteins that helps your body break down certain medicines. Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) (say “SIP-2-see-19”) is one certain protein in this family. It is the job of CYP2C19 to break down some medicines we use.
DNA holds your genetic code. It lives in every one of your body’s cells. Human DNA sequences are more than 99% alike between people. Still, there are specific areas in our DNA that are known to differ between people. This means that each person has small differences in their genes.
Differences in your DNA can change how well your body breaks down certain medicines. This is called pharmacogenetics (say FAR-mah-coh-je-NEH-tiks). If you break down a medicine too fast or too slowly, this may cause the medicine to not work as well or it may cause a side effect.
By testing your DNA, we can find DNA differences that can help us to see how well your CYP2C19 protein may work in you. The results of this test can help your doctor choose a certain medicine or a certain dose of medicine that is right for you. The results of your CYP2C19 gene test will place you into one of 4 groups:
CYP2C19 proteins break down many medicines that are often used. These medicines include:
These are the medicines that we know of right now that are broken down by CYP2C19 proteins and affected by CYP2C19 gene test results. Experts keep on finding new data about which medicines are affected by gene test results.
The result of your CYP2C19 gene test will place you into one of the 4 groups above. Knowing what group you are in may help your doctor to pick the right medicine and right dose for you.
For example, for voriconazole:
For example, for clopidogrel in certain situations*:
*It is important to note that the clopidogrel example above does not apply to all of the reasons someone might be taking it. The facts above have only been shown to apply to patients taking this medicine after percutaneous coronary intervention (a procedure used to treat narrowing or stenosis) often with a stent placed in the artery) of the coronary arteries (of the heart) for treatment of acute coronary syndromes.
We encourage you to talk with your doctor about your CYP2C19 gene test result. Follow your doctor’s instructions when taking any medicine. Do not stop using or change any of your medicines before speaking with your doctor.